Serum CRP and IL-6 levels after trauma - Not predictive of septic complications in 31 patients

被引:75
作者
Giannoudis, PV
Smith, MR
Evans, RT
Bellamy, MC
Guillou, PJ
机构
[1] St Jamess Univ Hosp, Dept Trauma & Orthopaed, Leeds, W Yorkshire, England
[2] St Jamess Univ Hosp, Dept Biochem, Leeds, W Yorkshire, England
[3] St Jamess Univ Hosp, Dept Anaesthet, Leeds, W Yorkshire, England
[4] St Jamess Univ Hosp, Dept Surg, Leeds, W Yorkshire, England
来源
ACTA ORTHOPAEDICA SCANDINAVICA | 1998年 / 69卷 / 02期
关键词
D O I
10.3109/17453679809117625
中图分类号
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学(修复外科学)];
学科分类号
摘要
We studied 31 blunt trauma victims, Injury Severity Score (ISS) mean 14 (9-57), for the pattern of release of C-reactive protein (CRP) and cytokine interleukin-6 (IL-6). Blood samples were taken on admission (within 6 hours of injury), as well as at 24 hours, and 3, 5 and 7 days. Serum CRP and IL-6 were measured by ELISA. Subsequent surgical events and sepsis were noted. Serum IL-6 levels on admission were considerably higher (median 135 pg mL(-1)) than our laboratory reference range (< 5 pg mL(-1)), slowly returning towards reference values during the study. Serum CRP levels were similar to laboratory normal values on admission (median 8.5 mg L-1 vs 7.5 mg L-1), reaching peak values (median 110 mg L-1) after 3 days. There was a correlation between IL-6 release and ISS but not between CRP and ISS. Patients undergoing surgery showed further increases in IL-6 and CRP levels postoperatively. Of 24 surgical patients, 9 developed postoperative sepsis. In blunt trauma patients, early assessment of the markers CRP or IL-6 were not useful for the diagnosis of sepsis. Levels of CRP following accidental or surgical trauma should be assessed with caution.
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页码:184 / 188
页数:5
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