CSF and serum immune parameters in Sydenham's chorea: evidence of an autoimmune syndrome?

被引：57

作者：

Church, AJ

Dale, RC

Cardoso, F

Candler, PM

Chapman, MD

Allen, ML

Klein, NJ

Lees, AJ

Giovannoni, G

机构：

[1] Inst Neurol, Neuroinflammat Dept, Neuroimmunol Unit, London WC1N 3BG, England

[2] Inst Child Hlth, Neurosci Unit, London, England

[3] Univ Fed Minas Gerais, Dept Psychiat & Neurol, Belo Horizonte, MG, Brazil

[4] Inst Child Hlth, Immunobiol Unit, London, England

[5] UCL Royal Free & Univ Coll Hosp Med Sch, Rita Lila Weston Inst Neurol Studies, London, England

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2003年 / 136卷 / 1-2期

关键词：

Sydenham's chorea; cytokines; IL-4; anti-basal ganglia antibodies; oligoclonal bands;

D O I：

10.1016/S0165-5728(03)00012-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Previous investigations have suggested that Sydenham's chorea (SC) may be an autoantibody mediated disorder. We examined this autoimmune hypothesis by measuring Th1 (IFN-gamma, IL-12) and Th2 (IL-4, IL-10) cytokines, oligoclonal bands (OCB) and anti-basal ganglia antibodies (ABGA). CSF IL-4 was elevated in 31% of acute SC and 50% of persistent SC. CSF IL-10 was also elevated in 31% of acute SC but 0% of persistent SC. CSF IFN-gamma was undetectable in all patients. Serums IL-4, IL-10 and IL-12 were elevated in acute compared to persistent SC. OCB were found in 46% of acute SC, ABGA were in 93% of acute SC and 50% of persistent SC was of IgG(1) and IgG(3) subclass. These findings support an autoantibody pathogenesis. (C) 2003 Elsevier Science B.V. All rights reserved.

引用

页码：149 / 153

页数：5

共 13 条

[1] Anti-basal ganglia antibodies in acute and persistent Sydenham's chorea [J].