Surface deformation of gold nanorod-loaded poly(DL-lactide-co-glycolide) nanoparticles after near infrared irradiation: an active and controllable drug release system

被引：16

作者：

Chu, Chih-Hang ^{[1
,2
]}

Wang, Yu-Chao ^{[3
]}

Tai, Lin-Ai ^{[3
]}

Wu, Li-Chen ^{[1
,2
]}

Yang, Chung-Shi ^{[1
,2
,3
]}

机构：

[1] Natl Chi Nan Univ, Dept Appl Chem, Puli, Taiwan

[2] Natl Chi Nan Univ, Grad Inst Biomed & Biomed Technol, Puli, Taiwan

[3] Natl Hlth Res Inst, Ctr Nanomed Res, Zhunan 350, Mialoli, Taiwan

来源：

JOURNAL OF MATERIALS CHEMISTRY | 2010年 / 20卷 / 16期

关键词：

MICROGELS; ENERGY; SILICA; PLGA;

D O I：

10.1039/b925651m

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A novel drug release method for poly(DL-lactide-co-glycolide) (PLGA) nanoparticles is reported. NIR laser irradiation (808 +/- 3 nm) on gold nanorods (GNRs) co-encapsulated in PLGA nanoparticles triggered surface protuberances (as studied by AFM) and induced rapid drug release. The NIR thus acts as a non-invasive external light source for active and controllable drug release from the PLGA/GNR composite nanoparticles. This type of drug delivery system may be of value in in vivo target delivery in the future.

引用

页码：3260 / 3264

页数：5

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