Should persons with acute myeloid leukemia have a transplant in first remission?

被引：24

作者：

Gale, R. P. ^{[1
]}

Wiernik, P. H. ^{[2
]}

Lazarus, H. M. ^{[3
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Med, Div Expt Med, Haematol Res Ctr, London SW7 2AZ, England

[2] Canc Res Fdn New York, Chappaqua, NY USA

[3] Case Western Reserve Univ, Univ Hosp Case Med Ctr, Cleveland, OH 44106 USA

来源：

LEUKEMIA | 2014年 / 28卷 / 10期

关键词：

STEM-CELL TRANSPLANTATION; AML; METAANALYSIS; TRIALS; ADULT; CONTROVERSIES; THERAPY; CANCER;

D O I：

10.1038/leu.2014.129

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Despite more than 40 years of extensive study, it remains uncertain which individuals, if any, with acute myelogenous leukemia (AML) in first remission should receive a blood cell or bone marrow transplant versus post-remission chemotherapy (or both). Nevertheless, there is a recent trend toward recommending more transplants in this setting. We consider four myths underlying this recommendation: (1) only individuals achieving second remission benefit from a transplant; (2) there is no effective therapy for relapse other than an allotransplant; (3) we can accurately predict which individuals with AML in first remission need a transplant; and (4) detection of minimal residual disease in first remission will resolve this controversy. We discuss these misconceptions and suggest approaches to resolve this issue.

引用

页码：1949 / 1952

页数：4

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