Bipolar disorder and age-related functional impairment

被引：15

作者：

Cacilhas, Alice Aita ^{[1
]}

da Silva Magalhaes, Pedro Vieira ^{[1
]}

Cereser, Keila Maria

Walz, Julio Cesar ^{[1
]}

Weyne, Fernanda ^{[1
]}

Rosa, Adriane Ribeiro ^{[1
,2
]}

Vieta, Eduard ^{[2
]}

Kapczinski, Flavio ^{[1
]}

机构：

[1] Univ Fed Rio Grande do Sul, Lab Psiquiatria Mol, HCPA, BR-90035003 Porto Alegre, RS, Brazil

[2] Univ Barcelona, Bipolar Disorders Program, Clin Inst Neurosci, Hosp Clin, Barcelona, Spain

来源：

REVISTA BRASILEIRA DE PSIQUIATRIA | 2009年 / 31卷 / 04期

关键词：

Bipolar disorder disability; Functioning; Ageing; Controlled study; Brazil; ALLOSTATIC LOAD; STRESS;

D O I：

10.1590/S1516-44462009000400012

中图分类号：

R749 [精神病学];

学科分类号：

100204 [神经病学];

摘要：

Objective: Although bipolar disorder is a major contributor to functional impairment worldwide, an independent impact of bipolar disorder and ageing on functioning has yet to be demonstrated. The objective of the present study was to evaluate the effect of bipolar disorder on age-related functional status using matched controls as a standard. Method: One-hundred patients with bipolar disorder and matched controls were evaluated for disability. Age-related effects controlled for confounders were cross-sectionally evaluated. Results: Patients were significantly more impaired than controls. Regression showed effects for aging in both groups. The effect, size, however, was significantly stronger in patients. Conclusion: Bipolar disorder was an important effect modifier of the age impact on functioning. While a longitudinal design is needed to effectively demonstrate this different impact, this study further depicts bipolar disorder as a chronic and progressively impairing illness.

引用

页码：354 / 357

页数：4

共 16 条

[1]

Validity of a Short Functioning Test (FAST) in Brazilian Outpatients with Bipolar Disorder [J].