AKT/PKB signaling: Navigating downstream

被引：6605

作者：

Manning, Brendan D.

Cantley, Lewis C.

机构：

[1] Harvard Univ, Sch Publ Hlth, Dept Genet & Complex Dis, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dept Syst Biol, Beth Israel Deaconess Med Ctr,Div Signal T, Boston, MA 02115 USA

来源：

CELL | 2007年 / 129卷 / 07期

关键词：

D O I：

10.1016/j.cell.2007.06.009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

The serine/threonine kinase Akt, also known as protein kinase B (PKB), is a central node in cell signaling downstream of growth factors, cytokines, and other cellular stimuli. Aberrant loss or gain of Akt activation underlies the pathophysiological properties of a variety of complex diseases, including type-2 diabetes and cancer. Here, we review the molecular properties of Akt and the approaches used to characterize its true cellular targets. In addition, we discuss those Akt substrates that are most likely to contribute to the diverse cellular roles of Akt, which include cell survival, growth, proliferation, angiogenesis, metabolism, and migration.

引用

收藏

页码：1261 / 1274

页数：14

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