Disinhibition of the contralateral motor cortex by low-frequency rTMS

被引：105

作者：

Plewnia, C

Lotze, M

Gerloff, C

机构：

[1] Univ Tubingen, Sch Med, Dept Neurol, Cort Physiol Res Grp, D-72076 Tubingen, Germany

[2] Inst Med Psychol & Behav Neurobiol, D-72074 Tubingen, Germany

来源：

NEUROREPORT | 2003年 / 14卷 / 04期

关键词：

human; intracortical inhibition; motor cortex; neuronal plasticity; neurophysiology; transcranial magnetic stimulation;

D O I：

10.1097/00001756-200303240-00017

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Low-frequency repetitive transcranial magnetic stimulation (rTMS) of the primary motor cortex (MI) results in a lasting decrease of motor evoked potentials (MEPs). Here we investigated the effects of supra-threshold rTMS (15 min, 1 Hz) to the left MI on the excitability of the stimulated and homologous (unstimulated) MI in healthy subjects by using single and double pulse TMS before and after rTMS. We found reduction of MEP amplitudes on the stimulated side and, most importantly, disinhibition of intracortical excitability of the homologous MI. This crossed effect of rTMS supports the concept of a physiological balance of reciprocal inhibitory projections and emphasizes that rTMS can induce remote effects that are relevant for the physiological interpretation of such interventions.

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收藏

页码：609 / 612

页数：4

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