Caveolae/raft-dependent endocytosis

被引：607

作者：

Nabi, IR ^{[1
]}

Le, PU ^{[1
]}

机构：

[1] Univ Montreal, Dept Pathol & Biol Cellulaire, Montreal, PQ H3C 3J7, Canada

来源：

JOURNAL OF CELL BIOLOGY | 2003年 / 161卷 / 04期

关键词：

endocytosis; caveolae; glycolipid rafts; caveolin; dynamin;

D O I：

10.1083/jcb.200302028

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Although caveolae are well-characterized subdomains of glycolipid rafts, their distinctive morphology and association with caveolins has led to their internalization being considered different from that of rafts. in this review, we propose that caveolae and rafts are internalized via a common pathway, caveolae/raft-dependent endocytosis, defined by its clathrin independence, dynamin dependence, and sensitivity to cholesterol depletion. The regulatory role of caveolin-1 and ligand sorting in this complex endocytic pathway are specifically addressed.

引用

页码：673 / 677

页数：5

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