Massive oxidation of phospholipid membranes leads to pore creation and bilayer disintegration

被引：93

作者：

Cwiklik, Lukasz ^{[1
]}

Jungwirth, Pavel ^{[1
]}

机构：

[1] Acad Sci Czech Republ, Inst Organ Chem & Biochem, Ctr Biomol & Complex Mol Syst, CR-16610 Prague 6, Czech Republic

来源：

CHEMICAL PHYSICS LETTERS | 2010年 / 486卷 / 4-6期

关键词：

OXIDIZED PHOSPHOLIPIDS; DYNAMICS; SIMULATIONS;

D O I：

10.1016/j.cplett.2010.01.010

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070305 [高分子化学与物理];

摘要：

Oxidation processes in membranes accompany various pathological conditions in organisms, nevertheless the influence of oxidation on the membrane structure is still poorly understood. Here we monitored the time evolution of a massively oxidized dioleoylphosphatidylcholine membrane in molecular dynamics simulations. Oxidation destabilized the membrane and, depending on its extent and type, in some cases even destroyed its structure. Creation of stable pores was observed as a direct consequence of oxidation and we describe here the molecular mechanisms of their formation. (C) 2010 Elsevier B. V. All rights reserved.

引用

页码：99 / 103

页数：5

共 20 条

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[2]

Molecular dynamics simulations of a fluid bilayer of dipalmitoylphosphatidylcholine at full hydration, constant pressure, and constant temperature [J].