The human polyomavirus, JCV, uses serotonin receptors to infect cells

被引：337

作者：

Elphick, GF

Querbes, W

Jordan, JA

Gee, GV

Eash, S

Manley, K

Dugan, A

Stanifer, M

Bhatnagar, A

Kroeze, WK

Roth, BL

Atwood, WJ ^{[1
]}

机构：

[1] Brown Univ, Dept Mol Microbiol & Immunol, Providence, RI 02912 USA

[2] Brown Univ, Grad Program Pathobiol, Providence, RI 02912 USA

[3] Brown Univ, Grad Program Mol Biol Cellular Biol & Biochem, Providence, RI 02912 USA

[4] Case Western Reserve Univ, Sch Med, Dept Biochem, Cleveland, OH 44106 USA

来源：

SCIENCE | 2004年 / 306卷 / 5700期

关键词：

D O I：

10.1126/science.1103492

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The human polyomavirus, JCV, causes the fatal demyelinating disease progressive multifocal leukoencephalopathy in immunocompromised patients. We found that the serotonergic receptor SHT2AR could act as the cellular receptor for JCV on human glial cells. The SHT2A receptor antagonists inhibited JCV infection, and monoclonal antibodies directed at 5HT(2A) receptors blocked infection of glial cells by JCV, but not by SV40. Transfection of 5HT(2A) receptor-negative HeLa cells with a 5HT(2A) receptor rescued virus infection, and this infection was blocked by antibody to the 5HT(2A) receptor. A tagged SHT2A receptor colocalized with labeled JCV in an endosomal compartment following internalization. Serotonin receptor antagonists may thus be useful in the treatment of progressive multifocal leukoencephalopathy.

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页码：1380 / 1383

页数：4

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