Elevated plasma thymosin-α1 levels in lung cancer patients

被引:14
作者
Sasaki, H [1 ]
Fujii, Y [1 ]
Masaoka, A [1 ]
Yamakawa, Y [1 ]
Fukai, I [1 ]
Kiriyama, M [1 ]
Saito, Y [1 ]
Matsui, H [1 ]
机构
[1] Nagoya City Univ, Sch Med, Dept Surg 2, Mizuho Ku, Nagoya, Aichi 467, Japan
关键词
thymosin-alpha; 1; lung cancer; immunoradiometric assay;
D O I
10.1016/S1010-7940(97)00269-8
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective: Prothymosin-alpha, the precursor of thymosin-alpha 1, may play a role in cell proliferation, and the plasma level of thymosin-alpha 1 may reflect the degree of proliferation of the tumor cells. Methods: Recently, a new sandwich immunoradiometric assay for thymosin-alpha 1 was developed using monoclonal and polyclonal antibodies. In this investigation, we used this assay to measure plasma and tissue level of thymosin-alpha 1 in 131 lung cancer patients. Results: We found that the mean plasma thymosin-alpha 1 levels in lung cancer patients were higher than in normal individuals (P < 0.001). However, half of the patients showed normal levels. Thymosin-alpha 1 levels correlated neither with the stage nor pathological subtype of the lung cancer, and did not decrease significantly in the 4 weeks after the resection of the tumor. Thymosin-alpha 1 levels of lung cancer patients with another cancer were higher than those without evidence of other cancers (P = 0.03). Survival of patients with normal levels of plasma thymosin-alpha 1 was significantly better than that with higher levels (P = 0.04). Conclusions: The plasma level of thymosin-alpha 1 may be used as a marker for the prognosis of lung cancer patients. Further investigations are warranted to determine its role in the lung cancer. (C) 1997 Elsevier Science B.V.
引用
收藏
页码:885 / 891
页数:7
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