High expression of uncoupling protein 2 in foetal liver

被引：31

作者：

Hodny, Z

Kolarova, P

Rossmeisl, M

Horáková, M

Nibbelink, M

Penicaud, L

Casteilla, L

Kopecky, J

机构：

[1] Acad Sci Czech Republ, Inst Physiol, CR-14220 Prague, Czech Republic

[2] Universite Paul Sabatier, Inst Louis Bugnard, Hop Rangueil, CNRS,UPRESA 5018, F-31054 Toulouse, France

来源：

FEBS LETTERS | 1998年 / 425卷 / 02期

关键词：

fetus; mitochondrion; macrophage; uncoupling protein; liver; rodent;

D O I：

10.1016/S0014-5793(98)00230-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

To assess the putative role of mitochondrial uncoupling protein 2 (UCP2) during perinatal development, its expression was analysed in mice and rats. Expression was detected in a large range of foetal tissues. A unique developmental pattern of UCP2 expression was found in liver, where the level of UCP2 mRNA was about 30-fold higher in foetuses than in adults (mice data), and started to decline immediately after birth. Neither UCP1 nor UCP3 mRNA was expressed in foetal liver. As in adult liver, immunohistochemical analysis suggested exclusive localisation of UCP2 in the monocyte/macrophage cells. Our results indicate a role of UCP2 in haematopoietic system development. (C) 1998 Federation of European Biochemical Societies.

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收藏

页码：185 / 190

页数：6

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