Cerebral quantitative susceptibility mapping predicts amyloid-β-related cognitive decline

被引：223

作者：

Ayton, Scott ^{[1
]}

Fazlollahi, Amir ^{[2
,3
]}

Bourgeat, Pierrick ^{[2
,3
]}

Raniga, Parnesh ^{[2
]}

Ng, Amanda ^{[4
]}

Lim, Yen Ying ^{[1
]}

Diouf, Ibrahima ^{[1
,2
]}

Farquharson, Shawna ^{[1
,4
]}

Fripp, Jurgen ^{[2
,3
]}

Ames, David ^{[5
,6
]}

Doecke, James ^{[2
,3
]}

Desmond, Patricia ^{[7
]}

Ordidge, Roger ^{[4
]}

Masters, Colin L. ^{[1
,3
]}

Rowe, Christopher C. ^{[1
,8
]}

Maruff, Paul ^{[1
,9
]}

Villemagne, Victor L. ^{[1
,8
]}

Salvado, Olivier ^{[2
,3
]}

Bush, Ashley I. ^{[1
,3
]}

机构：

[1] Univ Melbourne, Florey Inst Neurosci & Mental Hlth, Parkville, Vic, Australia

[2] CSIRO Hlth & Biosecur, Australian E Hlth Res Ctr, Brisbane, Qld, Australia

[3] Cooperat Res Ctr Mental Hlth, Parkville, Vic, Australia

[4] Univ Melbourne, Dept Anat & Neurosci, Parkville, Vic, Australia

[5] Natl Ageing Res Inst, Parkville, Vic, Australia

[6] Univ Melbourne, Acad Unit Psychiat Old Age, Parkville, Vic, Australia

[7] Univ Melbourne, Royal Melbourne Hosp, Dept Med & Radiol, Parkville, Vic, Australia

[8] Austin Hlth, Heidelberg, Vic, Australia

[9] Cogstate Ltd, Melbourne, Vic, Australia

来源：

BRAIN | 2017年 / 140卷

基金：

澳大利亚国家健康与医学研究理事会; 英国医学研究理事会;

关键词：

Quantitative Susceptibility Mapping; MRI; iron; Alzheimer's; cognitive decline; BRAIN IRON; IN-VIVO; HYPERPHOSPHORYLATED TAU; ALZHEIMER-DISEASE; OXIDATIVE STRESS; MEMORY DECLINE; MRI; ACCUMULATION; BIOMARKERS; SHRINKAGE;

D O I：

10.1093/brain/awx137

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

The large variance in cognitive deterioration in subjects who test positive for amyloid-beta by positron emission tomography indicates that convergent pathologies, such as iron accumulation, might combine with amyloid-beta to accelerate Alzheimer's disease progression. Here, we applied quantitative susceptibility mapping, a relatively new magnetic resonance imaging method sensitive to tissue iron, to assess the relationship between iron, amyloid-beta load, and cognitive decline in 117 subjects who underwent baseline magnetic resonance imaging and amyloid-beta positron emission tomography from the Australian Imaging, Biomarkers and Lifestyle study (AIBL). Cognitive function data were collected every 18 months for up to 6 years from 100 volunteers who were either cognitively normal (n = 64) or diagnosed with mild cognitive impairment (n = 17) or Alzheimer's disease (n = 19). Among participants with amyloid pathology (n = 45), higher hippocampal quantitative susceptibility mapping levels predicted accelerated deterioration in composite cognition tests for episodic memory [beta(standard error) = -0.169 (0.034), P = 9.2 x 10(-7)], executive function [b(standard error) = -0.139 (0.048), P = 0.004), and attention [beta(standard error) = -0.074 (0.029), P = 0.012]. Deteriorating performance in a composite of language tests was predicted by higher quantitative susceptibility mapping levels in temporal lobe [b(standard error) = -0.104 (0.05), P = 0.036] and frontal lobe [beta(standard error) = -0.154 (0.055), P = 0.006]. These findings indicate that brain iron might combine with amyloid-beta to accelerate clinical progression and that quantitative susceptibility mapping could be used in combination with amyloid-beta positron emission tomography to stratify individuals at risk of decline.

引用

页码：2112 / 2119

页数：8

共 48 条

[1]

In Vivo MRI Mapping of Brain Iron Deposition across the Adult Lifespan [J].