Desflurane hepatitis associated with hapten and autoantigen-specific IgG4 antibodies

被引：23

作者：

Anderson, James S.

Rose, Noel R.

Martin, Jackie L.

Eger, Edmond I.

Njoku, Dolores B.

机构：

[1] Johns Hopkins Med Instit, Dept Anesthesia & Crit Care Med, Baltimore, MD 21287 USA

[2] Johns Hopkins Med Instit, Dept Pathol, Baltimore, MD 21287 USA

[3] Johns Hopkins Med Instit, W Harry Feinstone Dept Mol Microbiol & Immunol, Baltimore, MD 21287 USA

[4] Anesthesia Consultants Associated, El Paso, TX USA

[5] Univ Calif San Francisco, San Francisco, CA 94143 USA

来源：

ANESTHESIA AND ANALGESIA | 2007年 / 104卷 / 06期

关键词：

D O I：

10.1213/01.ane.0000263275.10081.47

中图分类号：

R614 [麻醉学];

学科分类号：

100217 [麻醉学];

摘要：

BACKGROUND: Three cases of drug-induced liver injury (DILI) have been reported after desflurane anesthesia. However, no previous reports have detected serum autoantibodies such as that reported with DILI from halothane or isoflurane. METHODS AND RESULTS: We describe the first documentation of cytochrome P450 2E1 IgG4 autoantibodies, as well as 58 kDa endoplasmic reticulum protein and trifluoroacetyl chloride hapten-specific IgG4 antibodies, in a patient who developed DILI after desflurane anesthesia. CONCLUSIONS: These findings suggest that allergic and autoimmune mechanisms have critical roles in the development of desflurane DILI.

引用

页码：1452 / 1453

页数：2

共 16 条

[1]

Human cytochrome P450 2E1 is a major autoantigen associated with halothane hepatitis [J].