The role of Grb2-associated proteins in T-cell activation

被引:63
作者
Koretzky, GA [1 ]
机构
[1] UNIV IOWA,COLL MED,INTERDISCIPLINARY GRAD TRAINING PROGRAM IMMUNOL,IOWA CITY,IA 52242
来源
IMMUNOLOGY TODAY | 1997年 / 18卷 / 08期
关键词
D O I
10.1016/S0167-5699(97)01088-8
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Recently, attention has focused on :he role of adaptor proteins as modulators of signal transduction. Grb2, a cytosolic protein comprising two src-homology 3 (SH3) domains flanking a single SH2 domain, plays an important role in coupling receptor tyrosine kinases with downstream signals. In this article, proteins that associate with Grb2 in T cells are discussed, and models are presented suggesting how these interactions may be important for T-cell activation.
引用
收藏
页码:401 / 406
页数:6
相关论文
共 46 条
  • [1] BALDARI CT, 1995, ONCOGENE, V10, P1141
  • [2] THE TRUNCATION THAT GENERATED THE V-CBL ONCOGENE REVEALS AN ABILITY FOR NUCLEAR TRANSPORT, DNA-BINDING AND ACUTE TRANSFORMATION
    BLAKE, TJ
    HEATH, KG
    LANGDON, WY
    [J]. EMBO JOURNAL, 1993, 12 (05) : 2017 - 2026
  • [3] Interactions of Cbl with two adaptor proteins, Grb2 and Crk, upon T cell activation
    Buday, L
    Khwaja, A
    Sipeki, S
    Farago, A
    Downward, J
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (11) : 6159 - 6163
  • [4] BUDAY L, 1994, J BIOL CHEM, V269, P9019
  • [5] EPIDERMAL GROWTH-FACTOR REGULATES P21(RAS) THROUGH THE FORMATION OF A COMPLEX OF RECEPTOR, GRB2 ADAPTER PROTEIN, AND SOS NUCLEOTIDE EXCHANGE FACTOR
    BUDAY, L
    DOWNWARD, J
    [J]. CELL, 1993, 73 (03) : 611 - 620
  • [6] HUMAN SOS1 - A GUANINE-NUCLEOTIDE EXCHANGE FACTOR FOR RAS THAT BINDS TO GRB2
    CHARDIN, P
    CAMONIS, JH
    GALE, NW
    VANAELST, L
    SCHLESSINGER, J
    WIGLER, MH
    BARSAGI, D
    [J]. SCIENCE, 1993, 260 (5112) : 1338 - 1343
  • [7] DISASSEMBLY OF SON-OF-SEVENLESS PROTEINS FROM GRB2 DURING P21(RAS) DESENSITIZATION BY INSULIN
    CHERNIACK, AD
    KLARLUND, JK
    CONWAY, BR
    CZECH, MP
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (04) : 1485 - 1488
  • [8] CorbalanGarcia S, 1996, MOL CELL BIOL, V16, P5674
  • [9] DONOVAN JA, 1994, J BIOL CHEM, V269, P22921
  • [10] IDENTIFICATION OF A NUCLEOTIDE EXCHANGE-PROMOTING ACTIVITY FOR P21RAS
    DOWNWARD, J
    RIEHL, R
    WU, L
    WEINBERG, RA
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (15) : 5998 - 6002