Endocrine disruption and ovarian morphometric responses in rats following exposure to tetradifon

被引：26

作者：

Badraoui, Riadh ^{[1
]}

Abdelmoula, Nouha B. ^{[1
]}

Feki, Nozha ^{[1
]}

Ben Nasr, Hmed ^{[2
]}

Rebai, Tarek ^{[1
]}

机构：

[1] Med Fac Sfax, Histol Lab, Sfax 3029, Tunisia

[2] Med Fac Sfax, Pharmacol Lab, Sfax 3029, Tunisia

来源：

GENERAL AND COMPARATIVE ENDOCRINOLOGY | 2010年 / 166卷 / 02期

关键词：

Endocrine disruption; Ovarian follicles; Tetradifon; Reproductive toxicity; Rat; POLYCHLORINATED-BIPHENYLS; DAPHNIA-MAGNA; OXIDATIVE STRESS; THYROID-HORMONES; BREAST-CANCER; IN-UTERO; ORGANOCHLORINE; PESTICIDES; RISK; INSECTICIDES;

D O I：

10.1016/j.ygcen.2009.09.013

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

We have investigated whether exposure to tetradifon causes ovary injuries, disrupts folliculogenesis in rat and whether ovary hormones (estrogen and progesterone) to be affected by this endocrine-active agent. Female rats were exposed orally to a dose of 28.9 mg/kg/day for 6 or 12 weeks. After sacrifice, ovary glands were examined for morphometric changes. The serums were used to determine levels of 17 beta-estradiol and progesterone. Results showed no sign of toxicity. However, tetradifon promoted a significant increase in the percentage of atretic follicles in the 12-weeks treated rats. Number and the diameter of mature follicles (tertiary and preovulatory) were markedly diminished together with a reduction of the relative weight of ovaries. Compared with controls, the treated rats exhibited significant reduction in serum 17 beta-estradiol and progesterone levels. These results suggest an endocrine disruption by tetradifon which may interfere with ovarian follicles development in rat. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：268 / 272

页数：5

共 38 条

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