Analysis of antigen receptor signalling using mouse gene targeting

被引：17

作者：

Tybulewicz, VLJ ^{[1
]}

机构：

[1] Natl Inst Med Res, London NW7 1AA, England

来源：

CURRENT OPINION IN CELL BIOLOGY | 1998年 / 10卷 / 02期

关键词：

D O I：

10.1016/S0955-0674(98)80142-7

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Gene targeting in mice has enabled the study of antigen receptor signalling in primary lymphocytes. Furthermore, it has provided the tools to directly assess the function of individual signalling proteins by mutation of the genes that code for them. Some of the results that gene targeting has produced have confirmed previous views of the function of particular proteins. Others have given surprising results and overturned accepted viewpoints, (C) Current Biology Ltd ISSN 0955-0674.

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页码：195 / 204

页数：10

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