PAR1 signaling: more good than harm?

被引:23
作者
Ruf, W [1 ]
机构
[1] Scripps Res Inst, Dept Immunol, La Jolla, CA 92037 USA
关键词
D O I
10.1038/nm0303-258
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Two studies link signaling of the anticoagulant thrombomodulin-protein C pathway to successful implantation during pregnancy and protection from ischemic brain injury. The data call for a reassessment of the causes of pre-eclampsia, and also provide hope for a new type of stroke therapy (pages 331-337 and 338-342).
引用
收藏
页码:257 / 260
页数:4
相关论文
共 15 条
[1]   Efficacy and safety of recombinant human activated protein C for severe sepsis. [J].
Bernard, GR ;
Vincent, JL ;
Laterre, P ;
LaRosa, SP ;
Dhainaut, JF ;
Lopez-Rodriguez, A ;
Steingrub, JS ;
Garber, GE ;
Helterbrand, JD ;
Ely, EW ;
Fisher, CJ .
NEW ENGLAND JOURNAL OF MEDICINE, 2001, 344 (10) :699-709
[2]   Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective [J].
Cheng, T ;
Liu, D ;
Griffin, JH ;
Fernández, JA ;
Castellino, F ;
Rosen, ED ;
Fukudome, K ;
Zlokovic, BV .
NATURE MEDICINE, 2003, 9 (03) :338-342
[3]   Role of the thrombin receptor In development and evidence for a second receptor [J].
Connolly, AJ ;
Ishihara, H ;
Kahn, ML ;
Farese, RV ;
Coughlin, SR .
NATURE, 1996, 381 (6582) :516-519
[4]   PARticipation in inflammation [J].
Coughlin, SR ;
Camerer, E .
JOURNAL OF CLINICAL INVESTIGATION, 2003, 111 (01) :25-27
[5]   Trophoblast functions, angiogenesis and remodeling of the maternal vasculature in the placenta [J].
Cross, JC ;
Hemberger, M ;
Lu, Y ;
Nozaki, T ;
Whiteley, K ;
Masutani, M ;
Adamson, SL .
MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2002, 187 (1-2) :207-212
[6]   Tissue factor is required for uterine hemostasis and maintenance of the placental labyrinth during gestation [J].
Erlich, J ;
Parry, GCN ;
Fearns, C ;
Muller, M ;
Carmeliet, P ;
Luther, T ;
Mackman, N .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (14) :8138-8143
[7]  
Esmon CT, 2001, THROMB HAEMOSTASIS, V86, P51
[8]   Disruption of the endothelial cell protein C receptor gene in mice causes placental thrombosis and early embryonic lethality [J].
Gu, JM ;
Crawley, JTB ;
Ferrell, G ;
Zhang, FJ ;
Li, WH ;
Esmon, NL ;
Esmon, CT .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (45) :43335-43343
[9]   Endothelium-specific loss of murine thrombomodulin disrupts the protein C anticoagulant pathway and causes juvenile-onset thrombosis [J].
Isermann, B ;
Hendrickson, SB ;
Zogg, M ;
Wing, M ;
Cummiskey, M ;
Kisanuki, YY ;
Yanagisawa, M ;
Weiler, H .
JOURNAL OF CLINICAL INVESTIGATION, 2001, 108 (04) :537-546
[10]   The thrombomodulin-protein C system is essential for the maintenance of pregnancy [J].
Isermann, B ;
Sood, R ;
Pawlinski, R ;
Zogg, M ;
Kalloway, S ;
Degen, JL ;
Mackman, N ;
Weiler, H .
NATURE MEDICINE, 2003, 9 (03) :331-337