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The potential role of bisphosphonates in prostate cancer

被引：37
作者：
Oades, GM
Coxon, J
Colston, KW
机构：
[1] Univ London St Georges Hosp, Dept Urol, London, England
[2] Univ London St Georges Hosp, Dept Oncol Gastroenterol Endocrinol & Metab, London, England
[3] Univ London Sch Med, London, England
来源：
PROSTATE CANCER AND PROSTATIC DISEASES | 2002年 / 5卷 / 04期
关键词：
bisphosphonates; bone; metastases; prostate cancer;
D O I：
10.1038/sj.pcan.4500607
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Skeletal morbidity secondary to metastases and osteoporosis is common in patients with advanced prostate cancer. Despite the typically sclerotic nature of prostate cancer metastases, osteoclast mediated osteolysis may play a significant role. This review addresses the newly recognised antitumour effects of bisphosphonates in addition to their role in inhibiting osteoclast mediated bone resorption. Both preclinical and clinical evidence of a role for bisphosphonates in the treatment and prevention of bone metastases secondary to prostate cancer is assessed.
引用
收藏
页码：264 / 272
页数：9
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