Association of hypogammaglobulinemia with DRESS (Drug Rash with Eosinophilia and Systemic Symptoms)

被引：23

作者：

Boccara, Olivia

Valeyrie-Allanore, Laurence

Crickx, Beatrice

Descamps, Vincent

机构：

[1] Bichat Claude Bernard Hosp, Assistance Publ Hop Paris, Dept Dermatol, Paris, France

[2] Henri Mondor Hosp, Assistance Publ Hop Paris, Dept Dermatol, Creteil, France

来源：

EUROPEAN JOURNAL OF DERMATOLOGY | 2006年 / 16卷 / 06期

关键词：

DRESS; hypogammaglobulinemia; anticonvulsant hypersensitivity syndrome;

D O I：

10.1684/ejd.2006.0004

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 [皮肤病与性病学];

摘要：

The association of hypogammaglobulinemia was recently reported in anticonvulsant-associated DRESS. Hypogammaglobulinemia could be the consequence of hypoproteinemia in patients with erythroderma. To ascertain the association of hypogammaglobulinemia with DRESS we compared the prevalence of hypogammaglobulinemia in DRESS and in other cause of erythroderma. In a retrospective study, 39 consecutive patients with DRESS were compared to 52 patients with other causes of erythroderma hospitalized in the same period. Hypogammaglobulinemia was statistically significantly associated with DRESS (p = 0.022). This association was not limited to anticonvulsants (phenytoin, carbamazepin) and was observed with other drugs (allopurinol, tazocillin, ibuprofen, celecoxib, vancomycin).

引用

页码：666 / 668

页数：3

共 7 条

[1]

Carbamazepine-induced hypersensitivity syndrome associated with transient hypogammaglobulinaemia and reactivation of human herpesvirus 6 infection demonstrated by real-time quantitative polymerase chain reaction [J].