Evaluation of Blood Pressure in Spontaneously Diabetic Torii-Leprfa Rats

被引：17

作者：

Ishii, Yukihito ^{[1
]}

Maki, Mimi ^{[1
]}

Yamamoto, Hiromi ^{[1
]}

Sasase, Tomohiko ^{[1
]}

Kakutani, Makoto ^{[1
]}

Ohta, Takeshi ^{[1
]}

机构：

[1] Japan Tobacco Inc, Cent Pharmaceut Res Inst, Osaka 5691125, Japan

来源：

EXPERIMENTAL ANIMALS | 2010年 / 59卷 / 04期

关键词：

blood pressure; diabetes; SDT-fa/fa rat; TORII FATTY RATS; HYPERTENSION; PATHOPHYSIOLOGY; COMPLICATIONS; NEPHROPATHY; DISEASE;

D O I：

10.1538/expanim.59.525

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

090604 [动物药学];

摘要：

The Spontaneously Diabetic Torii-Lepr(fa) (SDT-fa/fa) rat, a new model of obese type 2 diabetes, shows obesity, hyperglycemia, and hyperlipidemia from 6 weeks of age. Diabetic complications such as nephropathy and cataract are observed with aging; however, blood pressure change with age has not previously been examined. In this study, blood pressure was periodically measured and the change was investigated. Blood pressure in male SDT-fa/fa rats was elevated at 8, 16, and 24 weeks of age, whereas the heart rate was not changed. In addition to hyperglycemia, hyperlipidemia, and proteinuria, hyperleptinemia and increased urine angiotensinogen were observed in SDT-fa/fa rats. Blood pressure and heart rate in the male original SDT (SDT-+/+) rat did not significantly change. In conclusion, the SDT-fa/fa rat is a promising model, showing significant hypertension with diabetes mellitus.

引用

页码：525 / 529

页数：5

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