How a home-grown T cell receptor interacts with a foreign landscape

被引：15

作者：

Rossjohn, Jamie ^{[1
]}

McCluskey, James

机构：

[1] Monash Univ, Sch Biomed Sci, Dept Biochem & Mol Biol, Prot Crystallog Unit, Clayton, Vic 3800, Australia

[2] Univ Melbourne, Dept Microbiol & Immunol, Parkville, Vic 3010, Australia

来源：

CELL | 2007年 / 129卷 / 01期

关键词：

D O I：

10.1016/j.cell.2007.03.018

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The ability of a T cell receptor (TCR) to directly recognize foreign (allogeneic)-major histocompatibility complex (MHC) molecules underlies T cell-mediated rejection in patients receiving allogeneic organ transplants. In this issue, Colf et al. (2007) reveal that instead of mimicking the interactions formed with a self MHC, a single TCR adopts a completely different strategy to recognize a foreign MHC.

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页码：19 / 20

页数：2

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