Molecular profiling of stem cells

被引：15

作者：

Ma, Li ^{[1
]}

Sun, Bingyun ^{[1
]}

Hood, Leroy ^{[1
]}

Tian, Qiang ^{[1
]}

机构：

[1] Inst Syst Biol, Seattle, WA 98103 USA

来源：

CLINICA CHIMICA ACTA | 2007年 / 378卷 / 1-2期

关键词：

Stem Cell; transcriptome; proteome; microarray; mass spectrometry; ChIP-chip;

D O I：

10.1016/j.cca.2006.12.016

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Stem cells, with their profound implication in development and enormous potential in regenerative medicine, have been the subject of extensive molecular profiling studies in search of better markers and regulatory schema governing self-renewal versus differentiation. In this review article, we will discuss current advancement in high throughput technologies dedicated to the transcriptome, protcome and genome-wide localization analyses, and how they have been adopted in molecular profiling of stem cells with an emphasis on embryonic stem cell (ESC), hematopoietic stem cell (HSC) and neural stem cell (NSC). (c) 2007 Elsevier B.V. All rights reserved.

引用

收藏

页码：24 / 32

页数：9

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