Long-term effects of chronic nicotine exposure on brain nicotinic receptors

被引：76

作者：

Besson, Morgane

Granon, Sylvie

Mameli-Engvall, Monica

Cloez-Tayaranit, Isabelle

Maubourguet, Nicolas

Cormier, Anne

Cazala, Pierre

David, Vincent

Changeux, Jean-Pierre ^{[1
]}

Faure, Philippe

机构：

[1] Inst Pasteur, CNRS, Unite Rech Associee 2182, Unite Neurobiol Integrat Syst Cholinerg, F-75724 Paris, France

[2] Karolinska Inst, Dept Physiol & Pharmacol, S-17177 Stockholm, Sweden

[3] Univ Bordeaux 1, CNRS, Unite Mixte Rech 5106, F-33405 Talence, France

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2007年 / 104卷 / 19期

关键词：

exploratory behaviors; homeostatis; ventral tegmental area; opponent process;

D O I：

10.1073/pnas.0702698104

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Chronic nicotine exposure results in long-term homeostatic regulation of nicotinic acetylcholine receptors (nAChRs) that play a key role in the adaptative cellular processes leading to addiction. However, the relative contribution of the different nAChR subunits in this process is unclear. Using genetically modified mice and pharmacological manipulations, we provide behavioral, electrophysiological, and pharmacological evidence for a long-term mechanism by which chronic nicotine triggers opposing processes differentially mediated by beta 2*- vs. alpha 7*nAChRs. These data offer previously undescribed insights into the understanding of nicotine addiction and the treatment of several human pathologies by nicotine-like agents chronically acting on beta 2*- or alpha 7*nAChRs.

引用

页码：8155 / 8160

页数：6

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