Distinct Profiles of Antibodies to Kaposi Sarcoma-Associated Herpesvirus Antigens in Patients with Kaposi Sarcoma, Multicentric Castleman Disease, and Primary Effusion Lymphoma

被引：25

作者：

Burbelo, Peter D. ^{[3
]}

Issa, Alexandra T. ^{[3
]}

Ching, Kathryn H. ^{[3
]}

Wyvill, Kathleen M. ^{[1
]}

Little, Richard F. ^{[1
]}

Iadarola, Michael J. ^{[3
]}

Kovacs, Joseph A. ^{[2
]}

Yarchoan, Robert ^{[1
]}

机构：

[1] NCI, HIV & AIDS Malignancy Branch, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

[2] NCI, Crit Care Med Dept, Ctr Clin, NIH, Bethesda, MD 20892 USA

[3] Natl Inst Dent & Craniofacial Res, Neurobiol & Pain Therapeut Sect, Lab Sensory Biol, NIH, Bethesda, MD USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2010年 / 201卷 / 12期

关键词：

DNA-SEQUENCES; EXPRESSION; PROTEIN; KSHV;

D O I：

10.1086/652869

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Antibody responses against lytic and latent Kaposi sarcoma (KS)-associated herpesvirus antigens were investigated in patients with KS, multicentric Castleman disease (MCD), and primary effusion lymphoma. Antibodies against the lytic antigen K8.1 were 5-fold higher in patients with MCD than those with KS, whereas antibodies to the sum of latent antigens v-cyclin and LANA were 27-fold higher in patients with KS, compared with patients with MCD (P < .001). The sum of anti-v-cyclin and anti-LANA antibody titers discriminated patients with KS from those with MCD and KS with 93% sensitivity and 83% specificity. These results suggest that antibody responses to lytic and latent KS-associated herpesvirus antigens differ in these diseases.

引用

页码：1919 / 1922

页数：4

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