L-755,807, a new non-peptide bradykinin binding inhibitor from an endophytic Microsphaeropsis sp.

被引：37

作者：

Lam, YKT ^{[1
]}

Hensens, OD ^{[1
]}

Ransom, R ^{[1
]}

Giacobbe, RA ^{[1
]}

Polishook, J ^{[1
]}

Zink, D ^{[1
]}

机构：

[1] MERCK SHARP & DOHME LTD,RES LABS,W POINT,PA 19486

来源：

TETRAHEDRON | 1996年 / 52卷 / 05期

关键词：

D O I：

10.1016/0040-4020(95)00985-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new metabolite, L-755,807, 1, was isolated from an endophytic Microsphaeropsis sp. in the course of searching for a bradykinin binding inhibitor. The structure of 1, including relative stereochemistry, was determined 1 showed an IC50 of 71 mu M in H-3-bradykinin binding to a cloned human B-2 receptor.

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页码：1481 / 1486

页数：6

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