Hyperbaric oxygen protects type II collagen in interleukin-1β-induced mandibular condylar chondrocyte via inhibiting the JNK/c-Jun signaling pathway

被引：18

作者：

Sun, Qi ^{[1
,2
]}

Wu, Gaoyi ^{[3
]}

Chen, Hang ^{[1
,2
]}

Chen, Lei ^{[1
,2
]}

Chen, Hongyu ^{[1
,2
]}

Zhu, Guoxiong ^{[3
]}

Zhao, Huaqiang ^{[1
,2
,4
]}

机构：

[1] Shandong Univ, Sch Stomatol, Jinan, Shandong, Peoples R China

[2] Shandong Prov Key Lab Oral Tissue Regenerat, Jinan, Shandong, Peoples R China

[3] Jinan Mil Gen Hosp, Dept Stomatol, Jinan, Shandong, Peoples R China

[4] Shandong Univ, Sch Stomatol, Dept Oral & Maxillofacial Surg, Jinan, Shandong, Peoples R China

来源：

ONCOTARGET | 2017年 / 8卷 / 36期

关键词：

hyperbaric oxygen; IL-1; beta; JNK; COL2; Sox-9; ARTICULAR-CARTILAGE; TERMINAL KINASE; SYNOVIAL-FLUID; TNF-ALPHA; EXPRESSION; PROMOTES; CELLS; BINDING; PHOSPHORYLATION; CHONDROGENESIS;

D O I：

10.18632/oncotarget.19294

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

The aim of this study was to explore the mechanisms of Hyperbaric oxygen (HBO) protective on interleukin-1 beta (IL-1 beta) induced rat's mandibular condylar chondrocytes. Chondrocytes were exposure to Hyperbaric oxygen after induced inflammatory by IL-1 beta. After that, the expression of p-JNK and c-Jun was increased significantly, while the Sox-9 was decreased significantly, Immunofluorescence results showed that the expression of p-JNK and p-c-Jun were decreased while the expression of Sox-9 and COL2 were increased in chondrocytes treated with IL-1 beta and selective JNK inhibitor. Hyperbaric oxygen might plays similar roles with the JNK-specific inhibitor SP600125, inducing the increase of Sox-9 and COL2 expression. On the whole, IL-1 beta induced inflammatory in chondrocytes by activating the JNK/c-Jun signaling pathway and down-regulate the expression of Sox-9 and COL2. However, Hyperbaric oxygen can inhibits IL-1 beta induced inflammatory response in chondrocytes though block the JNK/c-Jun signaling pathway and up-regulate the expression of Sox-9 and COL2.

引用

页码：60312 / 60323

页数：12

共 43 条

[1]

Control of chondrogenesis by the transcription factor Sox9 [J].