Structure and function of heparin and heparan sulfate; Heparinoid library and modification of FGF-activities

被引：66

作者：

Ishihara, M

Ono, K

机构：

[1] Natl Def Med Coll, Inst Res, Div Biomol Engn, Tokorozawa, Saitama 359, Japan

[2] Natl Def Med Coll, Dept Surg 2, Tokorozawa, Saitama 359, Japan

来源：

TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY | 1998年 / 10卷 / 52期

关键词：

fibroblast growth factor; heparan sulfate; heparin; heparinoid library; proteoglycan;

D O I：

10.4052/tigg.10.223

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

The various activities of heparin and heparan sulfate depend mainly on interactions of the polysaccharides with various functional proteins, mediated by specific domains with distinct saccharide sequences. For example, interaction of members of the FGF family with heparin and heparan sulfate requires different combinations of sulfate groups, hence different saccharide sequences. The sulfate groups mentioned above can be modified or substituted to introduce structural changes to the polysaccharides. Several such changes have been already performed on heparin in order to modulate the biological activities of FGF.

引用

页码：223 / 233

页数：11

共 36 条

[1]

CHARACTERIZATION OF HEPARAN-SULFATE OLIGOSACCHARIDES THAT BIND TO HEPATOCYTE GROWTH-FACTOR [J].