Diffraction, crystallography and microscopy beyond three dimensions: structural dynamics in space and time

被引:49
作者
Zewail, AH [1 ]
机构
[1] CALTECH, Arthur Amos Noyes Lab Chem Phys, Lab Mol Sci, Pasadena, CA 91125 USA
来源
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES | 2005年 / 363卷 / 1827期
关键词
crystallography; microscopy; diffraction; ultrafast dynamics; femtochemistry;
D O I
10.1098/rsta.2004.1513
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
In this article we highlight recent developments of ultrafast electron diffraction and crystallography at Caltech. These developments have made it possible to resolve transient structures, both spatially (0.01 Angstrom) and temporally (picosecond and now femtosecond), in the gas phase and condensed media-surfaces, interfaces, and crystals-with wide-ranging applications. With the extension to ultrafast electron microscopy, discussed here and elsewhere, we present an overview of one major research area at our centre, the Laboratory for Molecular Sciences.
引用
收藏
页码:315 / 329
页数:15
相关论文
共 22 条
[1]   Crystal structure of Escherichia coli MscS, a voltage-modulated and mechanosensitive channel [J].
Bass, RB ;
Strop, P ;
Barclay, M ;
Rees, DC .
SCIENCE, 2002, 298 (5598) :1582-1587
[2]   STRUCTURE OF THE PROTEIN SUBUNITS IN THE PHOTOSYNTHETIC REACTION CENTER OF RHODOPSEUDOMONAS-VIRIDIS AT 3A RESOLUTION [J].
DEISENHOFER, J ;
EPP, O ;
MIKI, K ;
HUBER, R ;
MICHEL, H .
NATURE, 1985, 318 (6047) :618-624
[3]   Femtosecond activation of reactions and the concept of nonergodic molecules [J].
Diau, EWG ;
Herek, JL ;
Kim, ZH ;
Zewail, AH .
SCIENCE, 1998, 279 (5352) :847-851
[4]   The structure of the potassium channel:: Molecular basis of K+ conduction and selectivity [J].
Doyle, DA ;
Cabral, JM ;
Pfuetzner, RA ;
Kuo, AL ;
Gulbis, JM ;
Cohen, SL ;
Chait, BT ;
MacKinnon, R .
SCIENCE, 1998, 280 (5360) :69-77
[5]   THE POTENTIAL AND LIMITATIONS OF NEUTRONS, ELECTRONS AND X-RAYS FOR ATOMIC-RESOLUTION MICROSCOPY OF UNSTAINED BIOLOGICAL MOLECULES [J].
HENDERSON, R .
QUARTERLY REVIEWS OF BIOPHYSICS, 1995, 28 (02) :171-193
[6]   3-DIMENSIONAL MODEL OF PURPLE MEMBRANE OBTAINED BY ELECTRON-MICROSCOPY [J].
HENDERSON, R ;
UNWIN, PNT .
NATURE, 1975, 257 (5521) :28-32
[7]   Direct imaging of transient molecular structures with ultrafast diffraction [J].
Ihee, H ;
Lobastov, VA ;
Gomez, UM ;
Goodson, BM ;
Srinivasan, R ;
Ruan, CY ;
Zewail, AH .
SCIENCE, 2001, 291 (5503) :458-462
[8]  
LOBASTOV VA, 2004, US PATENT PENDING
[9]  
LOBASTOV VA, 2003, ULTRAFAST OPTICS, V4, P413
[10]   Dynamics of water in biological recognition [J].
Pal, SK ;
Zewail, AH .
CHEMICAL REVIEWS, 2004, 104 (04) :2099-2123