Postsurgical reduction of serum lipoproteins: Interleukin-6 and the acute-phase response

被引:48
作者
Akgun, S
Ertel, NH
Mosenthal, A
Oser, W
机构
[1] New Jersey Hlth Care Syst, Dept Vet Affairs, Med Serv, E Orange, NJ 07018 USA
[2] New Jersey Hlth Care Syst, Dept Vet Affairs, Surg Serv, E Orange, NJ 07018 USA
[3] Univ Med & Dent New Jersey, New Jersey Med Sch, Newark, NJ 07103 USA
来源
JOURNAL OF LABORATORY AND CLINICAL MEDICINE | 1998年 / 131卷 / 01期
关键词
D O I
10.1016/S0022-2143(98)90083-X
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
In a previous retrospective study, we reported a significant reduction in serum cholesterol levels following major surgery, and speculated on the possible role of cytokines in this reduction. The purpose of this article is to report a prospective study of the association of cytokines with postoperative changes in serum lipoprotein levels. Serum samples were obtained from 11 male patients before and at intervals for up to 10 days after surgery, and were assayed for total cholesterol CTC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), cortisol, tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6), and interferon-gamma (IFN-gamma). LDL-C was calculated. The TC showed a 27.9% decrease, from a mean of 4.27 mmol/L to 3.08 mmol/L (p < 0.001) after surgery, reaching a nadir at 24 hours and returning to preoperative values in 7 to 10 days. A similar decrease was noted in the HDL-C and LDL-C levels. 11-6 levels increased from a mean baseline value of 6 pg/ml to a peak of 143 pg/ml at 24 hours (p < 0.0006). There was an inverse relationship between TC and IL-6 levels, with r = -0.51 for the entire curve and r = -0.90 for the cholesterol nadir with the IL-6 peak. The other cytokines did not show significant changes. We conclude that TC and its fractions decrease to a nadir and that IL-6 increases to a peak approximately 24 hours after major surgery. There is a significant inverse correlation between TC and IL-6, suggesting a possible role of 11-6 in postoperative changes in serum lipoproteins.
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收藏
页码:103 / 108
页数:6
相关论文
共 24 条
[1]  
AKGUN S, 1993, TURK J MED SCI, V17, P123
[2]   ASSOCIATION BETWEEN SERUM INTERLEUKIN-6 AND SERUM 3,5,3'-TRIIODOTHYRONINE IN NONTHYROIDAL ILLNESS [J].
BOELEN, A ;
SCHIPHORST, MCP ;
WIERSINGA, WM .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1993, 77 (06) :1695-1699
[3]   INTERFERONS - FROM VIRUS INHIBITOR TO MODULATOR OF AMINO-ACID AND LIPID-METABOLISM [J].
BORDEN, EC ;
ROSENZWEIG, IB ;
BYRNE, GI .
JOURNAL OF INTERFERON RESEARCH, 1987, 7 (05) :591-596
[4]   CYTOKINES DECREASE APOLIPOPROTEIN ACCUMULATION IN MEDIUM FROM HEP G2 CELLS [J].
ETTINGER, WH ;
VARMA, VK ;
SORCITHOMAS, M ;
PARKS, JS ;
SIGMON, RC ;
SMITH, TK ;
VERDERY, PB .
ARTERIOSCLEROSIS AND THROMBOSIS, 1994, 14 (01) :8-13
[5]  
GRUNFELD C, 1991, AM J MED, V90, P154, DOI 10.1016/0002-9343(91)80154-E
[6]  
Hamblin AS, 1993, CYTOKINES CYTOKINE R, P65
[7]   CHANGES IN SERUM-LIPID CONCENTRATIONS DURING 1ST 24 HOURS AFTER MYOCARDIAL-INFARCTION [J].
JACKSON, R ;
SCRAGG, R ;
MARSHALL, R ;
WHITE, H ;
OBRIEN, K ;
SMALL, C .
BRITISH MEDICAL JOURNAL, 1987, 294 (6587) :1588-1589
[8]  
KUSHNER I, 1991, NEW TR CYT, P3
[9]  
KYLE LH, 1952, J LAB CLIN MED, V39, P605
[10]   TIME COURSE FOR THE CHANGES OF SERUM-LIPOPROTEINS AND APOLIPOPROTEIN-T CONCENTRATIONS AFTER MAJOR SURGICAL TRAUMA IN MAN [J].
LINDH, A ;
LINDHOLM, M ;
HOLMQUIST, L ;
CARLSON, LA .
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION, 1986, 10 (03) :265-273