Glutathione peroxidase-1 contributes to the neuroprotection seen in the superoxide dismutase-1 transgenic mouse in response to ischemia/reperfusion injury

被引：47

作者：

Crack, PJ

Taylor, JA

de Haan, JB

Kola, I

Hertzog, P

Iannello, RC

机构：

[1] Monash Univ, Monash Inst Reprod & Dev, Ctr Funct Genom & Human Dis, Melbourne, Vic 3004, Australia

[2] Pharmacia Corp, Kalamazoo, MI USA

来源：

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM | 2003年 / 23卷 / 01期

关键词：

glutathione peroxidase-1; superoxide dismutase; knockout mouse; cerebral ischemia; oxidative stress;

D O I：

10.1097/01.WCB.0000035181.38851.71

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The authors hypothesized that glutathione peroxidase-1 (Gpx-1) contributes to the neuroprotection seen in the superoxide dismutase-1 transgenic (Sod-1 tg) mouse. To investigate this hypothesis, they crossed the Gpx-1 -/- mouse with the Sod-1 tg and subjected the cross to a mouse model of ischemia/reperfusion. Two hours of focal cerebral ischemia followed by 24 hours of reperfusion was induced via intraluminal suture. The Sod-1 tg/Gpx-1 -/- cross exhibited no neuroprotection when infarct volume was measured; indeed, infarct volume increased in the Sod-1 tg/Gpx-1 -/- cross compared with the wild-type mouse. Our results suggest that Gpx-1 plays an important regulatory role in the protection of neural cells in response to ischemia/reperfusion injury.

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收藏

页码：19 / 22

页数：4

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