Ribonucleolytic rat torpedoes RNA polymerase II

被引：34

作者：

Luo, WF ^{[1
]}

Bentley, D ^{[1
]}

机构：

[1] Univ Colorado, Hlth Sci Ctr, Dept Biochem & Mol Genet, Aurora, CO 80045 USA

来源：

CELL | 2004年 / 119卷 / 07期

关键词：

D O I：

10.1016/j.cell.2004.11.041

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Three recent papers reveal a fascinating link between pol II termination and ribonucleolytic decay of the nascent transcript by a 5'-3' exonuclease (yeast Rat1 and human Xrn2). The exonuclease travels with pol II and gains access to the nascent RNA after endonucleolytic cleavage at the poly(A) site or at a second cotranscriptional cleavage site (CoTC). It is then thought to track in a 5'-3' direction like a guided torpedo that ultimately helps dissociate the RNA polymerase elongation complex.

引用

页码：911 / 914

页数：4

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