Countercurrent chromatography (CCC) and its versatile application as an industrial purification & production process

This paper describes the versatile operation of CCC,. its potential for scale up and compares its operational performance with HPLC as a generic preparative purification process. In the words of the UK Biology & Biotechnology Science Research Council (BBSRC), there is a need for a "generation of new, robust, and usable techniques for bioprocess intensification and simplification" and, in particular, technology that can be scaled from laboratory to process scale easily and cheaply without any fundamental change to the principle of separation. CCC offers the potential to do this.