Colorimetric phage-based assay for detection of rifampin-resistant Mycobacterium tuberculosis

被引：16

作者：

McNerney, Ruth

Mallard, Kim

Urassa, Honorathy M. R.

Lemma, Eshetu

Donoghue, Helen D.

机构：

[1] Univ London London Sch Hyg & Trop Med, Dept Infect & Trop Dis, London WC1E 7HT, England

[2] Ethiopian Hlth & Nutr Res Inst, Infect & Other Dis Res Dept, Addis Ababa, Ethiopia

[3] UCL, Dept Infect, Ctr Infect Dis & Int Hlth, London, England

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2007年 / 45卷 / 04期

关键词：

D O I：

10.1128/JCM.02028-06

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Tests based on bacteriophage replication enable rapid screening of Mycobacterium tuberculosis for drug resistance. We describe a novel broth-based colorimetric method for detecting phage replication. When clinical isolates were tested by this novel method, high concordance was observed with both the traditional phage assay and gene mutation analysis for detection of resistance to rifampin.

引用

收藏

页码：1330 / 1332

页数：3

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