Antigen presentation in the lung

被引:78
作者
Holt, PG
机构
[1] TVW Telethon Inst Child Hlth Res, Div Cell Biol, W Perth, WA 6872, Australia
[2] Univ Western Australia, Ctr Child Hlth Res, Perth, WA 6009, Australia
关键词
D O I
10.1164/ajrccm.162.supplement_3.15tac2
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
Studies from our laboratory and elsewhere have Implicated populations of dendritic cells in lung and airway tissues as key regulators of both qualitative and quantitative aspects of T cell responses to local antigenic challenge. Under steady state conditions, they are specialized for uptake of antigen, and require additional maturation signals for full expression of their T cell-stimulating activity. Their functional phenotype appears to be controlled via a complex series of interactions with both bone marrow-derived, mesenchymal, and possibly neuroendocrine cells; failure(s) in one or more of these regulatory interactions may be important etiologic and/or pathogenic factors in a variety of respiratory immunoinflammatory disease.
引用
收藏
页码:S151 / S156
页数:6
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[1]   REGULATION OF THE IMMUNOSTIMULATORY ACTIVITY OF RAT PULMONARY INTERSTITIAL DENDRITIC CELLS BY CELL-CELL INTERACTIONS AND CYTOKINES [J].
ARMSTRONG, LR ;
CHRISTENSEN, PJ ;
PAINE, R ;
CHEN, GH ;
MCDONALD, RA ;
LIM, TK ;
TOEWS, GB .
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 1994, 11 (06) :682-691
[2]  
BILYK N, 1995, IMMUNOLOGY, V86, P231
[3]  
Bingisser RM, 1998, J IMMUNOL, V160, P5729
[4]   ACCUMULATION OF LANGERHANS CELLS ON THE EPITHELIAL SURFACE OF THE LOWER RESPIRATORY-TRACT IN NORMAL SUBJECTS IN ASSOCIATION WITH CIGARETTE-SMOKING [J].
CASOLARO, MA ;
BERNAUDIN, JF ;
SALTINI, C ;
FERRANS, VJ ;
CRYSTAL, RG .
AMERICAN REVIEW OF RESPIRATORY DISEASE, 1988, 137 (02) :406-411
[5]   REGULATION OF RAT PULMONARY DENDRITIC CELL IMMUNOSTIMULATORY ACTIVITY BY ALVEOLAR EPITHELIAL CELL-DERIVED GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR [J].
CHRISTENSEN, PJ ;
ARMSTRONG, LR ;
FAK, JJ ;
CHEN, GH ;
MCDONALD, RA ;
TOEWS, GB ;
PAINE, R .
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 1995, 13 (04) :426-433
[6]   Human lung dendritic cells have an immature phenotype with efficient mannose receptors [J].
Cochand, L ;
Isler, P ;
Songeon, F ;
Nicod, LP .
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 1999, 21 (05) :547-554
[7]   FLUCTUATION OF THE NUMBER OF CD-1(T6)-POSITIVE DENDRITIC CELLS, PRESUMABLY LANGERHANS CELLS, IN THE NASAL-MUCOSA OF PATIENTS WITH AN ISOLATED GRASS-POLLEN ALLERGY BEFORE, DURING, AND AFTER THE GRASS-POLLEN SEASON [J].
FOKKENS, WJ ;
VROOM, TM ;
RIJNTJES, E ;
MULDER, PGH .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1989, 84 (01) :39-43
[8]   CD-1 (T6), HLA-DR-EXPRESSING CELLS, PRESUMABLY LANGERHANS CELLS, IN NASAL-MUCOSA [J].
FOKKENS, WJ ;
VROOM, TM ;
RIJNTJES, E ;
MULDER, PGH .
ALLERGY, 1989, 44 (03) :167-172
[9]   ALVEOLAR MACROPHAGE ACCESSORY CELL-FUNCTION IN BRONCHIAL-ASTHMA [J].
GANT, V ;
CLUZEL, M ;
SHAKOOR, Z ;
REES, PJ ;
LEE, TH ;
HAMBLIN, AS .
AMERICAN REVIEW OF RESPIRATORY DISEASE, 1992, 146 (04) :900-904
[10]   Antigen presenting cells in the nasal mucosa of patients with allergic rhinitis during allergen provocation [J].
Godthelp, T ;
Fokkens, WJ ;
Kleinjan, A ;
Holm, AF ;
Mulder, PGH ;
Prens, EP ;
Rijntes, E .
CLINICAL AND EXPERIMENTAL ALLERGY, 1996, 26 (06) :677-688