The High Mobility Group A1 Gene: Transforming Inflammatory Signals into Cancer?

被引：107

作者：

Resar, Linda M. S. ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Baltimore, MD 21205 USA

来源：

CANCER RESEARCH | 2010年 / 70卷 / 02期

基金：

美国国家卫生研究院;

关键词：

TRANSGENIC MICE; UTERINE TUMORIGENESIS; HMG-I/Y; GROUP-A; EXPRESSION; PROTEINS; TRANSCRIPTION; ONCOGENE; CELLS;

D O I：

10.1158/0008-5472.CAN-09-1212

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

High mobility group A1 (HMGA1) is highly expressed during embryogenesis and in poorly differentiated cancers, and high levels portend a poor prognosis in some tumors. HMGA1 induces oncogenic transformation in cultured cells and causes aggressive cancers in transgenic mice, whereas blocking it interferes with transformation in experimental models. These findings suggest a pivotal role for HMGA1 in cancer. This review focuses on two recently described HMGA1 transcriptional targets that mediate inflammatory signals and drive malignant transformation because they could serve as biomarkers or therapeutic targets. Further elucidation of HMGA1 function in transformation promises to have a major impact on our war on cancer. Cancer Res; 70(2); 436-9. (C)2010 AACR.

引用

页码：436 / 439

页数：4

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