Distribution of CCR5-Δ32, CCR2-64I, and SDF1-3′ a mutations in populations from the Brazilian Amazon region

被引：11

作者：

Carvalhaes, FADL ^{[1
]}

Cardoso, GL

Hamoy, IG

Liu, YT

Guerreiro, JF

机构：

[1] Fed Univ Para, Lab Human & Med Genet, Dept Pathol, Ctr Biol Sci, BR-66075900 Belem, Para, Brazil

[2] Univ Oxford, John Radcliffe Hosp, Weatherall Inst Mol Med, Oxford OX3 9DS, England

来源：

HUMAN BIOLOGY | 2004年 / 76卷 / 04期

关键词：

CCR5; CCR2; SDF1; HIV-1; chemokine receptors; Brazilians; Amazon region;

D O I：

10.1353/hub.2004.0052

中图分类号：

Q98 [人类学];

学科分类号：

030303 ;

摘要：

The frequency distribution of the CCR5-Delta32, CCR2-64I, and SDF1-3'A alleles was studied in the urban population of Belem and in Afro-Brazilians, Amerindians, and Japanese immigrants in the state of Para, Brazil. The results suggest that Amerindians may be genetically more susceptible to HIV-1 infection and disease progression than the other human groups studied.

引用

页码：643 / 646

页数：4

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