Selective speech motor, syntax and cognitive deficits associated with bilateral damage to the putamen and the head of the caudate nucleus: a case study

被引:97
作者
Pickett, ER [1 ]
Kuniholm, E
Protopapas, A
Friedman, J
Lieberman, P
机构
[1] Brown Univ, Dept Cognit & Linguist Sci, Providence, RI 02912 USA
[2] Brown Univ, Dept Clin Neurosci, Providence, RI 02912 USA
[3] Roger Williams Canc Med Ctr, Dept Neurol, Providence, RI USA
关键词
basal ganglia; sequencing; language; timing; frontostriatal circuits; speech deficits;
D O I
10.1016/S0028-3932(97)00065-1
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Deficits in speech production, sentence comprehension and abstract reasoning occurred in a subject having profound bilateral damage to the putamen and the caudate nucleus. Acoustic analyses indicated that the subject's speech was degraded due to inappropriate sequencing of articulatory gestures that involve different articulatory structures. Transitions between sounds were slow and often did not achieve target configurations. The subject had a 14% error rate comprehending distinctions in meaning conveyed by syntax in English sentences; normal controls make virtually no errors in this test. Cognitive deficits involving impaired sequencing occurred: the subject had a 70% error rate on the Odd Man Out test when making decisions within a single category. Cognitive perseveration occurred when the subject was asked to shift categories. In contrast, performance was within normal ranges in tests of lexical access and memory. The pattern of deficits provides evidence for basal ganglia involvement in the regulation of sequencing across modalities. (C) 1998 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:173 / 188
页数:16
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