Cystothiazoles A and B, new bithiazole-type antibiotics from the myxobacterium Cystobacter fuscus

被引：107

作者：

Ojika, M

Suzuki, Y

Tsukamoto, A

Sakagami, Y ^{[1
]}

Fudou, R

Yoshimura, T

Yamanaka, S

机构：

[1] Nagoya Univ, Grad Sch Bioagr Sci, Chikusa Ku, Nagoya, Aichi 46401, Japan

[2] Ajinomoto Co Inc, Cent Res Labs, Basic Res Labs, Kawasaki Ku, Kawasaki, Kanagawa 210, Japan

来源：

JOURNAL OF ANTIBIOTICS | 1998年 / 51卷 / 03期

关键词：

D O I：

10.7164/antibiotics.51.275

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

New bithiazole-type antibiotics, cystothiazoles A (C20H26N2O4S2) and B (C20H26N2O5S2), have been isolated from a culture broth of the myxobacterium, Cystobacter fuscus. The gross structures of these compounds were elucidated by spectroscopic analysis, and their absolute stereochemistry was determined by chemical degradation of cystothiazole A. Cystothiazole A inhibits fungi and human tumor cells, whereas it is inactive against bacteria. The antifungal activity appears to result from the inhibition of submitochondrial NADH oxidation. Although these compounds are structurally related to the known antibiotic myxothiazol, cystothiazole A was more active against fungi and less cytotoxic than myxothiazol.

引用

页码：275 / 281

页数：7

共 9 条

[1] Epothilons A and B: Antifungal and cytotoxic compounds from Sorangium cellulosum (Myxobacteria) - Production, physico-chemical and biological properties [J].