Hydrogen-rich Saline Alleviated the Hyperpathia and Microglia Activation via Autophagy Mediated Inflammasome Inactivation in Neuropathic Pain Rats

被引：50

作者：

Chen, Hongguang ^{[1
,2
]}

Zhou, Chunjing ^{[3
]}

Xie, Keliang ^{[1
,2
]}

Meng, Xiaoyin ^{[4
]}

Wang, Yaoqi ^{[1
,2
]}

Yu, Yonghao ^{[1
,2
]}

机构：

[1] Tianjin Med Univ Gen Hosp, Dept Anesthesiol, Tianjin 300052, Peoples R China

[2] Tianjin Res Inst Anesthesiol, Tianjin 300052, Peoples R China

[3] Tianjin 4th Ctr Hosp, Dept Anesthesiol, Tianjin 300140, Peoples R China

[4] Tianjin Hosp, Dept Gynaecol & Obstet, Tianjin 300211, Peoples R China

来源：

NEUROSCIENCE | 2019年 / 421卷

基金：

中国国家自然科学基金;

关键词：

neuropathic pain; inflammasome; autophagy; hydrogen; SPINAL NERVE LIGATION; NLRP3; INFLAMMASOME; MITOCHONDRIAL DYSFUNCTION; NMDA RECEPTOR; MITOPHAGY; PATHWAY; MODEL; INJURY; BRAIN; CONTRIBUTES;

D O I：

10.1016/j.neuroscience.2019.10.046

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Neuropathic pain is a complication after a spinal nerve injury. The inflammasomes are now identified to be responsible for triggering inflammation in neuropathic pain. Autophagy participates in the process of neuropathic pain and can regulate the inflammasome activation in different diseases. Our previous research reported that hydrogen exerted a protective effect against neuropathic pain. Therefore, we focused on the mechanism and role of autophagy and inflammasome, by which hydrogen alleviated the hyperpathia induced by neuropathic pain. The results showed that neuropathic pain stimulated activation of inflammasome NLRP3 and autophagy pathway in the microglial cells of the spinal cord. The inhibition of NLRP3 inhibited the hyperpathia induced by spinal nerve litigation surgery. The absence of autophagy aggravated the inflammasome activity and hyperpathia. Hydrogen promoted autophagy related protein expression, inhibited the inflammasome NLRP3 pathway activation, and relieved the hyperpathia induced by neuropathic pain. Hydrogen treatment could alleviate hyperpathia by autophagy-mediated NLRP3 inactivation. (C) 2019 IBRO. Published by Elsevier Ltd. All rights reserved.

引用

页码：17 / 30

页数：14

共 61 条

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