Neuroprotection in the Newborn Infant

被引：57

作者：

Gonzalez, Fernando F. ^{[1
,2
]}

Ferrier, Donna M. ^{[1
,2
,3
]}

机构：

[1] Univ Calif San Francisco, Neonatal Brain Disorders Lab, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Dept Pediat, San Francisco, CA 94143 USA

[3] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94143 USA

来源：

CLINICS IN PERINATOLOGY | 2009年 / 36卷 / 04期

关键词：

Neonatal stroke; Hypoxia; Ischemia; Neuroprotection; Neurogenesis; ISCHEMIC BRAIN-INJURY; ENDOTHELIAL GROWTH-FACTOR; NITRIC-OXIDE SYNTHASE; FOCAL CEREBRAL-ISCHEMIA; NEURAL STEM-CELLS; NEONATAL HYPOXIA-ISCHEMIA; WHOLE-BODY HYPOTHERMIA; ERYTHROPOIETIN ENHANCES NEUROGENESIS; PROVIDES PARTIAL NEUROPROTECTION; MILD SYSTEMIC HYPOTHERMIA;

D O I：

10.1016/j.clp.2009.07.013

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Neonatal brain injury is an important cause of death and disability, with pathways of oxidant stress, inflammation, and excitotoxicity that lead to damage that progresses over a long period of time. Therapies have classically targeted individual pathways during early phases of injury, but more recent therapies such as growth factors may also enhance cell proliferation, differentiation, and migration over time. More recent evidence suggests combined therapy may optimize repair, decreasing cell injury while increasing newly born cells.

引用

页码：859 / +

页数：23

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