Antibiotic efflux pumps in prokaryotic cells:: occurrence, impact on resistance and strategies for the future of antimicrobial therapy

被引:143
作者
Van Bambeke, F [1 ]
Glupczynski, Y
Plésiat, P
Pechère, JC
Tulkens, PM
机构
[1] Catholic Univ Louvain, Unite Pharmacol Cellulaire & Mol, B-1200 Brussels, Belgium
[2] Catholic Univ Louvain, Microbiol Lab, Clin Univ Mt Godinne, Yvoir, Belgium
[3] CHU Jean Minjoz, Bacteriol Lab, Besancon, France
[4] Univ Geneva, Dept Microbiol, Geneva, Switzerland
关键词
antibiotic; efflux; transporters; prokaryotes; resistance;
D O I
10.1093/jac/dkg224
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
[No abstract available]
引用
收藏
页码:1055 / 1065
页数:11
相关论文
共 118 条
[1]   Effects of NorA inhibitors on in vitro antibacterial activities and postantibiotic effects of levofloxacin, ciprofloxacin, and norfloxacin in genetically related strains of Staphylococcus aureus [J].
Aeschlimann, JR ;
Dresser, LD ;
Kaatz, GW ;
Rybak, MJ .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1999, 43 (02) :335-340
[2]  
AHMED M, 1993, J BIOL CHEM, V268, P11086
[3]   Involvement of an active efflux system in the natural resistance of Pseudomonas aeruginosa to aminoglycosides [J].
Aires, JR ;
Köhler, T ;
Nikaido, H ;
Plésiat, P .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1999, 43 (11) :2624-2628
[4]   Cloning and characterization of SmeDEF, a novel multidrug efflux pump from Stenotrophomonas maltophilia [J].
Alonso, A ;
Martínez, JL .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2000, 44 (11) :3079-3086
[5]   Development, validation, and application of PCR primers for detection of tetracycline efflux genes of gram-negative bacteria [J].
Aminov, RI ;
Chee-Sanford, JC ;
Garrigues, N ;
Teferedegne, B ;
Krapac, IJ ;
White, BA ;
Mackie, RI .
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2002, 68 (04) :1786-1793
[6]  
Arcangioli MA, 1999, FEMS MICROBIOL LETT, V174, P327, DOI 10.1016/S0378-1097(99)00161-5
[7]   Differential expression of over 60 chromosomal genes in Escherichia coli by constitutive expression of MarA [J].
Barbosa, TM ;
Levy, SB .
JOURNAL OF BACTERIOLOGY, 2000, 182 (12) :3467-3474
[8]  
Barrett J F, 2001, Curr Opin Investig Drugs, V2, P212
[9]   CLONING AND SEQUENCE-ANALYSIS OF AN ESCHERICHIA-COLI GENE CONFERRING BICYCLOMYCIN RESISTANCE [J].
BENTLEY, J ;
HYATT, LS ;
AINLEY, K ;
PARISH, JH ;
HERBERT, RB ;
WHITE, GR .
GENE, 1993, 127 (01) :117-120
[10]   CHARACTERIZATION OF THE NONENZYMATIC CHLORAMPHENICOL RESISTANCE (CMLA) GENE OF THE IN4 INTEGRON OF TN1696 - SIMILARITY OF THE PRODUCT TO TRANSMEMBRANE TRANSPORT PROTEINS [J].
BISSONNETTE, L ;
CHAMPETIER, S ;
BUISSON, JP ;
ROY, PH .
JOURNAL OF BACTERIOLOGY, 1991, 173 (14) :4493-4502