High frequency of rearrangement of the RET protooncogene (RET/PTC) in Chinese papillary thyroid carcinomas

被引：33

作者：

Lee, CH

Hsu, LS

Chi, CW

Chen, GD

Yang, AH

Chen, JY ^{[1
]}

机构：

[1] Acad Sinica, Inst Biomed Sci, Taipei 11529, Taiwan

[2] Natl Def Med Ctr, Grad Inst Life Sci, Taipei 11529, Taiwan

[3] Vet Gen Hosp, Dept Surg, Taipei 11529, Taiwan

[4] Vet Gen Hosp, Dept Med Res, Taipei 11529, Taiwan

[5] Vet Gen Hosp, Dept Pathol, Taipei 11529, Taiwan

[6] Natl Yang Ming Univ, Taipei 11529, Taiwan

来源：

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM | 1998年 / 83卷 / 05期

关键词：

D O I：

10.1210/jc.83.5.1629

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The activation of RET protooncogene, through chromosomal translocation, is unique to papillary thyroid carcinomas. Rearrangement of the RET kinase domain to 3 partner genes has been described, of which the RET/PTC1 is the most common. To investigate the frequency of RET rearrangement in Chinese papillary thyroid carcinomas, we have performed RT-PCR to amplify specific RET/PTC transcripts. Among the papillary thyroid carcinomas of 11 patients examined, we have identified 2 containing RET/PTC1, 3 containing RET/PTC2, and 1 containing RET/PTC3 oncogenes. Although the cause of the high frequency of RET/PTC oncogenes in Chinese papillary thyroid carcinomas is unknown, our study suggests that RET rearrangement is an important genetic lesion underlying the development of thyroid papillary carcinoma in Taiwan.

引用

页码：1629 / 1632

页数：4

共 24 条

[1] MOLECULAR CHARACTERIZATION OF A THYROID TUMOR-SPECIFIC TRANSFORMING SEQUENCE FORMED BY THE FUSION OF RET TYROSINE KINASE AND THE REGULATORY SUBUNIT RI-ALPHA OF CYCLIC AMP-DEPENDENT PROTEIN KINASE-A [J].