The role of mannitol in alleviating renal injury during extracorporeal shock wave lithotripsy

被引：48

作者：

Ogiste, JS ^{[1
]}

Nejat, RJ ^{[1
]}

Rashid, HH ^{[1
]}

Greene, T ^{[1
]}

Gupta, M ^{[1
]}

机构：

[1] Columbia Univ Coll Phys & Surg, New York Presbyterian Hosp, Squier Urol Clin, New York, NY 10032 USA

来源：

JOURNAL OF UROLOGY | 2003年 / 169卷 / 03期

关键词：

kidney; kidney calculi; lithotripsy; mannitol; iatrogenic disease;

D O I：

10.1097/01.ju.0000050320.56369.01

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Purpose: We determined the role of mannitol in preventing or alleviating renal injury during extracorporeal shock wave lithotripsy (ESWL, Dornier Medical Systems, Inc., Marietta, Georgia). Materials and Methods: Patients undergoing ESWL were randomized to receive mannitol or control. Change in the levels of urinary enzymes, beta2-microglobulin and microalbumin were compared in the groups before and after the procedure. Results: Mannitol treated patients had a statistically significant decrease in beta2-microglobulin excretion after ESWL compared with the control group. Conclusions: Mannitol may serve a protective function by decreasing the amount of renal injury caused by ESWL for renal calculous disease.

引用

页码：875 / 877

页数：3

共 13 条

[1]

URINARY ENZYME LEVELS AFTER EXTRACORPOREAL SHOCK-WAVE LITHOTRIPSY (ESWL) [J].