Pregnancy and birth after intracytoplasmic sperm injection with totally immotile sperm recovered from the ejaculate

Objective: To report the birth of two healthy children after intracytoplasmic sperm injection (ICSI) with totally immotile spermatozoa recovered from the ejaculate. Design: Retrospective case report. Setting: University-based hospital. Patient(s): Four couples in whom spermatozoa recovered from the ejaculate were totally immotile but presented normal vitality scores. Intervention(s): Therapeutical IVF-ET attempts coupled with ICSI. Main Outcome Measure(s): Fertilization and pregnancy results after ICSI. Results: With random sperm injection, 19 of the 36 injected oocytes showed normal fertilization and cleavage. One of four patients had a twin pregnancy that resulted in birth of two healthy children. Conclusion(s): In cases in which totally immotile ejaculated sperm present normal vitality scores, normal clinical outcomes can be achieved by using the usual random sperm selection during conventional ICSI. (C) 1997 by American Society for Reproductive Medicine.