Expression of murine novel zinc finger proteins highly homologous to Drosophila ovo gene product in testis

被引：25

作者：

Masu, Y

Ikeda, S

Okuda-Ashitaka, E

Sato, E

Ito, S

机构：

[1] Kansai Med Univ, Dept Med Chem, Osaka 570, Japan

[2] Kansai Med Univ, Dept Anesthesiol, Osaka 570, Japan

[3] Tohoku Univ, Grad Sch Agr, Anim Reprod Unit, Aoba Ku, Sendai, Miyagi 981, Japan

来源：

FEBS LETTERS | 1998年 / 421卷 / 03期

关键词：

cDNA cloning; zinc finger protein; ovo; homologue; spermatogenesis;

D O I：

10.1016/S0014-5793(97)01567-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have cloned two isoforms of cDNAs encoding novel zinc finger proteins, One form encodes a 274-amino acid protein containing an acidic amino acid and serine-rich domain and a zinc finger domain which shows high sequence homology to that of Drosophila Ovo protein, The other form encodes a 179-amino acid protein containing only the zinc finger domain, Expression of both proteins possessing an antigenic epitope in COS cells revealed that they are localized in the nucleus. The 1.3-kbp mRNAs are predominantly expressed in testis, and the expression increases from 3 weeks postnatal, implying that these proteins may play important roles in the development of the testes. (C) 1998 Federation of European Biochemical Societies.

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页码：224 / 228

页数：5

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