Effects of thioperamide on locomotor activity and on memory processes

被引：20

作者：

Ghi, P ^{[1
]}

Di Carlo, G ^{[1
]}

Molinengo, L ^{[1
]}

机构：

[1] Univ Turin, Dipartimento Anat Farmacol & Med Legale, Turin, Italy

来源：

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 1998年 / 22卷 / 02期

关键词：

memory consolidation; open field; rat locomotor activity; thioperamide;

D O I：

10.1016/S0278-5846(98)00011-6

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

1. Rats were tested in an open field. Thioperamide given ip. 30 minutes before the tests produced an increase of locomotor activity at 2 mg/kg and no behavioral effect at 5 mg/kg. 2. The repetition of the open field tests caused a reduction of ambulation in three successive tests. This effect was increased by thioperamide 2 and 5 mg/kg given after the tests, suggesting that this compound improved memory consolidation.

引用

页码：387 / 395

页数：9

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