Antigenic stimulation by BCG vaccine as an in vivo driving force for SIV replication and dissemination

被引：42

作者：

Cheynier, R

Gratton, S

Halloran, M

Stahmer, I

Letvin, NL

Wain-Hobson, S

机构：

[1] Inst Pasteur, Unite Retrovirol Mol, F-75724 Paris 15, France

[2] Harvard Univ, Sch Med, Div Viral Pathogenesis, Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA

来源：

NATURE MEDICINE | 1998年 / 4卷 / 04期

关键词：

D O I：

10.1038/nm0498-421

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The impact of antigenic stimulation on the dynamics of simian immunodeficiency virus (SIV) replication was studied following repeated intravenous BCC inoculation of a SIV infected macaque. At the site of a delayed type hypersensitivity reaction to purified protein derivative of M. tuberculosis, a distinctive SIV variant was noted, probably as a result of the infiltration of activated antigen-specific T cell clones as opposed to infection by blood borne virus in situ. The dynamics of SIV quasispecies in peripheral blood suggests sequential waves of viral replication, illustrating the role of antigenic stimulation as a driving force in viral dissemination and pathogenesis.

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页码：421 / 427

页数：7

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