Bowels control brain: gut hormones and obesity

被引：123

作者：

Field, Benjamin C. T. ^{[1
]}

Chaudhri, Owais B. ^{[1
]}

Bloom, Stephen R. ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Div Endocrinol Diabet & Metab, London W12 0NN, England

来源：

NATURE REVIEWS ENDOCRINOLOGY | 2010年 / 6卷 / 08期

基金：

英国医学研究理事会;

关键词：

GLUCAGON-LIKE PEPTIDE-1; Y GASTRIC BYPASS; HUMAN PANCREATIC-POLYPEPTIDE; TYPE-2; DIABETES-MELLITUS; PLASMA GHRELIN LEVELS; INCREASES FOOD-INTAKE; FREE-FEEDING RATS; CCK-A AGONIST; BODY-WEIGHT; GLYCEMIC CONTROL;

D O I：

10.1038/nrendo.2010.93

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Food intake and energy expenditure are tightly regulated by the brain, in a homeostatic process that integrates diverse hormonal, neuronal and metabolic signals. The gastrointestinal tract is an important source of such signals, which include several hormones released by specialized enteroendocrine cells. These hormones exert powerful effects on appetite and energy expenditure. This Review addresses the physiological roles of peptide YY, pancreatic polypeptide, islet amyloid polypeptide, glucagon-like peptide 1, glucagon, oxyntomodulin, cholecystokinin and ghrelin and discusses their potential as targets for the development of novel treatments for obesity.

引用

收藏

页码：444 / 453

页数：10

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