Control of reactive site in palladium-catalyzed Grignard cross-coupling of arenes containing both bromide and triflate

被引：83

作者：

Kamikawa, T ^{[1
]}

Hayashi, T ^{[1
]}

机构：

[1] KYOTO UNIV,FAC SCI,DEPT CHEM,SAKYO KU,KYOTO 60601,JAPAN

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 40期

关键词：

D O I：

10.1016/S0040-4039(97)01655-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Reaction of 4-bromophenyl triflate (1) with phenylmagnesium bromide in the presence of 5 mol % of PdCl2(dppp) gave 97% yield of 4-bromobiphenyl (2a), which was formed by selective replacement of triflate in 1 by phenyl. On the other hand, bromide in 1 was substituted with the phenyl Grignard reagent selectively by use of PdCl2(meo-mop)(2) to give 4-biphenyl triflate (3a) in high yield. The selective substitution was demonstrated to take place at the oxidative addition step to a palladium(0) species in a stoichiometric reaction of 1 with palladium(0) phosphine complexes. (C) 1997 Elsevier Science Ltd.

引用

页码：7087 / 7090

页数：4

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